Dr. John Thuita

Dean - SAFS

Biography

Dr. John Thuita is ………………………………………………………………………..

Specialties: Agriculture, …………………………………………….

Title	Cited by	Year
The pathogenicity of blood stream and central nervous system forms of Trypanosoma brucei rhodesiense trypanosomes in laboratory mice: a … K Ndungu, J Thuita, G Murilla, J Kagira, J Auma, P Mireji, G Ngae, … F1000Research 11, 260		2022
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model K Ndung’u, GA Murilla, JK Thuita, GN Ngae, JE Auma, PK Gitonga, … PLoS One 15 (11), e0229060	7*	2020
Broad diversity of simian immunodeficiency virus infecting Chlorocebus species (African green monkey) and evidence of cross‐species infection in Papio anubis (olive baboon) in … R Nyamota, V Owino, EK Murungi, J Villinger, M Otiende, D Masiga, … Journal of Medical Primatology 49 (4), 165-178	3	2020
Phenotypic characteristics distinguishing bloodstream form and central nervous form of Trypanosoma brucei rhodesiense. K Ndung’u, GA Murilla, JK Thuita, JM Kagira, PO Mireji, GN Ngae, …	1	2020
In vitro antiplasmodial, cytotoxicity assay and partial chemical characterization of Kenyan Physalis peruviana L.(Solanaceae family) extracts PK Kamau, Z Ng’ang’a, FM Njeruh, J Thuita Journal of Medicinal Plants Research	2	2020
Route of inoculation influences Trypanosoma congolense and Trypanosoma brucei brucei virulence in Swiss white mice K Ndungu, D Thungu, F Wamwiri, P Mireji, G Ngae, P Gitonga, J Mulinge, … PLoS One 14 (6), e0218441	12	2019
Evaluation of safety of aqueous, methanol and dichloromethane crude extracts of the Kenyan physalis peruviana l (cape gooseberry) in male Wistar albino rats ZW Ng’ang’a, P Gakio, FM Njeruh, J Thuita, P Karanja		2018
Coenzyme Q10 and endogenous antioxidants neuro-protect mice brain against deleterious effects of melarsoprol and Trypanasoma brucei rhodesiense GK Nyambati, JN Nyariki, JK Thuita IISTE	7	2018
Differential virulence and tsetse fly transmissibility of Trypanosoma congolense and Trypanosoma brucei strains PK Gitonga, GA Murilla, K Ndung’u, PC Thande, FN Wamwiri, JE Auma, … Onderstepoort Journal of Veterinary Research 84 (1), 1-10	17	2017
Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys DM Mwangangi, JM Ndung’u, JM Kagira, R Mdachi, JK Thuita, M Ngotho		2017
The prickly pear cactus (Opuntia fiscus-indica) cladode extracts modulate blood sugar in swiss white albino mice PM Mokua, O Mayunzu, M Obonyo, J Thuita, J Mutuku, J Rutto, G Murilla International Journal of Diabetes Research	10	2016
Comparative pathogenicity of Trypanosoma brucei rhodesiense strains in Swiss white mice and Mastomys natalensis rats MW Muchiri, K Ndung’u, JK Kibugu, JK Thuita, PK Gitonga, GN Ngae, … Acta tropica 150, 23-28	8	2015
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys JK Thuita, KK Wolf, GA Murilla, AS Bridges, DW Boykin, JN Mutuku, Q Liu, … PLoS neglected tropical diseases 9 (2), e0003409	27*	2015
Kenya Trypanosomiasis Research Institute cryobank for human and animal trypanosome isolates to support research: opportunities and challenges GA Murilla, K Ndung’u, JK Thuita, PK Gitonga, DT Kahiga, JE Auma, … PLoS Neglected Tropical Diseases 8 (5), e2747	17	2014
Kenya Trypanosomiasis Research Institute Cryobank for Human and Animal Trypanosome Isolates to Support Research: Opportunities and Challenges AM Grace, K Ndung’u, JK Thuita, PK Gitonga, DT Kahiga, JE Auma, …		2014
Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis JK Thuita, KK Wolf, GA Murilla, Q Liu, JN Mutuku, Y Chen, AS Bridges, … PLoS neglected tropical diseases 7 (6), e2230	25	2013
Infectra®-kit: A device for restraining mice and confining tsetse flies during trypanosome infection transmission experiments K Ndung’u, JK Kibugu, PK Gitonga, JK Thuita, JE Auma, SK Gitonga, … Acta tropica 126 (2), 146-149	2	2013
Safety JK Thuita, KK Wolf, GA Murilla, Q Liu, JN Mutuku Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet …	1	2013
Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypano JK Thuita, KK Wolf, GA Murilla, Q Liu, JN Mutuku, Y Chen, AS Bridges, … PLOS		2013
Biological and pharmacological investigations of novel diamidines in animal models of human African trypanosomiasis JK Thuita Ph. D. thesis. University of Basel, Basel, Switzerland	7	2013
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis JK Thuita, MZ Wang, JM Kagira, CL Denton, MF Paine, RE Mdachi, … PLoS neglected tropical diseases 6 (7), e1734	42	2012
Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey JK Thuita, MZ Wang, JM Kagira, CL Denton, MF Paine		2012
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense M Ngotho, JM Kagira, C Kariuki, N Maina, JK Thuita, DM Mwangangi, … Acta tropica 119 (1), 14-18	25	2011
Diamidines for human African trypanosomiasis WD Wilson, HP De Koningº, CA Olson, G Pohlig Current opinion in investigational drugs 11 (8), 876-883	137	2010
Use of TrypTectCIAAT to determine the effectiveness of treatment of Trypanosoma brucei rhodesiense infections in vervet monkeys (Chlorocebus aethiops) and man SM Karanja, JM Ngaira, JK Thuita, CW Gichuki The Journal of Protozoology Research 20 (1), 10-20	1	2010
Comparative evaluation of anticoagulatory activity of ethylenediamine tetra-acetic acid (EDTA) and heparin for haematological analysis. JK Kibugu, MW Muchiri, N Mbugua, JN Mwangi, JK Thuita Bulletin of Animal Health and Production in Africa 58 (4), 409-411	1	2010
A semi-longitudinal study of trypanosomiasis and its vectors in donkeys (Equus africanus asinus, Fitzinger) in the Lamu archipelago– P Mukiria, R Mdachi, J Thuita, J Mutuku, K Wanjala, J Omolo, G Mulugeta, … Proceedings of12th KARI Biennial Scientific Conference	5	2010
Efficacy of the novel diamidine compound 2, 5-Bis (4-amidinophenyl)-furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in … RE Mdachi, JK Thuita, JM Kagira, JM Ngotho, GA Murilla, JM Ndung’u, … Antimicrobial agents and chemotherapy 53 (3), 953-957	48	2009
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis JK Thuita, SM Karanja, T Wenzler, RE Mdachi, JM Ngotho, JM Kagira, … Acta tropica 108 (1), 6-10	99	2008
Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis JK Thuita, JM Kagira, D Mwangangi, E Matovu, CMR Turner, D Masiga PLoS Neglected Tropical Diseases 2 (5), e238	70	2008
Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human Afr… J Thuita, J Mutuku, J Kagira, S Karanja		2008
Hematological changes in vervet monkeys (Chlorocebus aethiops) during eight months’ adaptation to captivity JM Kagira, M Ngotho, JK Thuita, NW Maina, J Hau American Journal of Primatology: Official Journal of the American Society of …	57*	2007
Hematological changes in Vervet monkeys (Chlorocebus aethiops) during eight months adaptation to captivity J Hau, JM Kagira, MJ Ngothol, JK Thuita, NW Maina JOURNAL OF THE AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 46 (4 …		2007
Lymphosarcoma in adult African green monkeys (Chlorocebus aethiops) JM Kagira, M Ngotho, JK Thuita, HE Jensen, J Hau Journal of Laboratory Animal Scienc	1	2007
Development of a rodent model for late stage rhodesian sleeping sickness JM Kagira, M Ngotho, J Thuita The Journal of Protozoology Research 17 (2), 48-56	22	2007
Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys JM Kagira, JK Thuita, M Ngotho, R Mdachi, DM Mwangangi, JM Ndung’u African Journal of health sciences 13 (3), 59-65	57	2006
Influence of cyclophosphamide on the haematological profile of laboratory bred African soft-furred rats (Mastomys natalensis) JM Kagira, N Maina, JK Thuita, M Ngotho, J Hau	10	2005
Proinflammatory Cytokine Expression in the Early Phase of Trypanosoma brucei rhodesiense Infection in Vervet Monkeys (Cercopithecus aethiops) N Maina, JM Ngotho, T Were, JK Thuita, DM Mwangangi, JM Kagira, … Infection and immunity 72 (5), 3063-3065	34	2004
FUNGAL AND PARASITIC INFECTIONS-Proinflammatory Cytokine Expression in the Early Phase of Trypanosoma brucei rhodesiense Infection in Vervet Monkeys (Cercopithecus aethiops) N Maina, JM Ngotho, T Were, JK Thuita, DM Mwangangi, JM Kagira, … Infection and Immunity 72 (5), 3063-3065		2004
Prospects of an alternative late stage vervet monkey model of T. b. rhodesiense without induction with trypanocidals JK Thuita, JM Ngotho, JM Kagira, DM Mwangangi, JM Ndung’u Proceedings 5th EANETT Workshop, Bagamoyo, Tanzania	3	2003
Use of DB289 for treatment of vervet monkeys infected with early stage T. b. rhodesiense JM Ndung’u, RE Mdachi, JM Ngotho, JKT Thuita, JE Hall, R Tidwell Proceedings of the 27th ISCTRC meeting, Pretoria, South Africa 27	3	2003
Use of DB289 for treatment of early-stage T. b. rhodesiense infections in Swiss white mice JM Ngotho, JM Kagira, JKT Thuita, RE Mdachi, JM Ndung’u Proceedings of the 27th Meeting of ISCTRC, Pretoria, South Africa	3	2003
Coenzyme Q10 prevented full blown splenomegaly and decreased melarsoprol-induced reactive encephalopathy in mice infected with Trypanosoma brucei rhodesiense JN Nyariki, JK Thuita, GK Nyambati, AO Isaac Journal of Coastal Life Medicine	4	1997
The influence of pH and usefulness of buffered diluent on the recovery of micro-organisms from honey JK Thuita University of Nairobi		1992
The influence of PH on the recovery of contaminating micro-organisms from honey JK Thuita University of Nairobi		1992
Antimicrobial evaluation and phytochemical screening of aqueous and dichloromethane crude extracts of Kenyan Physalis Peruviana L (Cape Gooseberry) FM Njeruh, J Thuita
HAEMATOLOGY OF EXPERIMENTAL TRYPANOSOMA BRUCEI RHODESIENSE INFECTION IN VERVET MONKEYS HEMATOLOGIE DE L’INFECTION EXPERIMENTALE DE TRYPANOSOMA BRUCEI RHODESIENSE CHEZ LES … JM Kagira, JK Thuita, JM Ngotho, DM Mwangangi, JM Ndung’u

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